p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasome
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چکیده
منابع مشابه
Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex.
Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, the SCA7 gene product. To gain insight into ataxin-7 function and to decipher the molecular mechanisms of neurodegeneration in SCA7, a two-hybrid assay was performed to identif...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2007
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2007.04460.x